Which of the following is least likely to have splenomegaly persisting to adulthood?
- β+ thalassaemia intermedia
- Sickle cell anaemia
- Sickle cell trait
- Sickle β+ thalassaemia
Which of the following is most commonly characterised by iron overload?
- Alpha thalassaemia
- β+ thalassaemia major
- Sickle cell disease
- Hb D
A Rh positive woman from South-east Asia delivers a neonate with hydrops fetalis. What is the likely cause?
- α-thalassaemia
- β-thalassaemia Major
- δ-thalassaemia
- Haemoglobin E diseases
Which of The following haemoglobinopathy does not give protection against malaria
- Sickle cell anaemia
- Haemoglobin C disease
- Beta thalassaemia
- Haemoglobin D
Which of the following statements about sickle cell anaemia is not true?
- Hemoglobin S polymerises under hypoxic conditions
- Hypoxia and dehydration increase the risk of sickling
- Haemoglobin F increases the risk of sickling
- Nigeria, democratic republic of Congo and India are the three countries with the highest number of patients with sickle cell anaemia
Answer 1
B. Sickle cell anaemia – Recurrent splenic infractions from early childhood result in a small fibrotic spleen
Answer 2
B. Patients with β+ thalassaemia major accumulate iron because of increased intestinal iron absorption and blood transfusion
Answer 3
A. α-thalassaemia. Barts hydrops faetalis results from a severe form of alpha thalassaemia resulting from the loss of all four alpha globin genes. This mainy seen in south east asia and Thailand.
Answer 4
D. Haemoglobin D does not protect against malaria, other haemoglobinopathies do
Answer 5
C. Haemoglobin F decreases the risk of sickling
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