Acute Lymphoblastic Leukaemia… Evaluation of Splenomegaly 17 May 201717 May 2017 The spleen is a secondary lymphoid organ that lies in intraperitoneally in the left hypochondrium, abuting the diaphragm. It spans from the 9th to 11th rib and weighs between 150-200g. Spleen…
Anemia… Sickle β-Thalassaemia 24 Sep 201624 Sep 2016 Sickle cell anaemia and β-thalassaemia are two common haemoglobinopathies. Co-inheritance of the two is called sickle β-thalassaemia. Sickle β-thalassaemia seen in Africa, throughout the Mediterranean, Arabian Peninsula and sporadically in india.…
Anemia… Evolution and Spread of HbS 20 Jun 201620 Jun 2016 The gene for β globin (OMIM is present on chromosome 11 (11p15.4) along with other globin genes (ε, γ, γ and δ). This is known as the β-globin cluster .…
Anemia… Sickle Cells 24 Aug 201331 Aug 2013 Sickle Cells 40X Sickle Cells - 100X Sickle Cells - 100X The three photomicrographs above show sickle cells from a patients with sickle cell anemia. Sickle cell anaemia occurs because…
Acute Promyelocytic Leukemia… Faggot Cells 30 May 201213 Jun 2012 The old/middle english term faggot means a bundle of sticks bound together as fuel (faggot is derived the latin term fascis which is also the root for the term fasiculus).…
Anemia… Sickle Haemoglobin and Varients 14 May 201213 Jun 2012 Substitution of the amino acid glutamic acid by valine at position 6 of the beta globin gene (HBB glu6val) results in a mutant haemoglobin that polymerizes at low oxygen pressure. This…
Anemia… Pappenheimer Bodies 2 Oct 20112 Oct 2011 Described by Pappenheimer in 1945, the Pappenheimer bodies are basophilic erythrocytic inclusions that are usually located at the periphery of the cell. They contain iron and stain with Prussian blue.…
Anemia… Detoxifying Haemoglobin 22 Jun 201127 Jun 2011 It is difficult to imagine that a molecule as essential to life as haemoglobin (hb) would need a detoxification mechanism. Anyone who has treated a patient with severe intravascular haemolysis…
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