Erythropoiesis… Regulation of Haematopoiesis 23 Mar 2019 All blood cells arise from the haemaopoietic stem cell. The path along which the stem cell progeny matures is dictated by the needs of the body. Examples of this include…
Erythropoiesis… Etiology of Polycythaemia 13 Jul 201313 Jul 2013 The terms polycythemia and erythrocytosis though used interchangeably describe different entities. Polycythemia (Gk, polys + kytos, cell, haima, blood) is an absolute increase in the mass of red cells. Erythrocytosis refers to only increase in the concentration…
Erythropoiesis… The Haemopoietic Stem Cell 17 May 201323 Mar 2019 The red blood cell count is about 4.5 X1012 red blood, The white blood cell count between between 4-10 X109/L and platelet count is 150-400X109/L. The red blood cells have…
Bone Marrow Examination… Normoblast Maturation 7 Mar 20138 Mar 2013 The image above shows three polychromatophilic normoblasts. The one on the left is the least mature and the one on the right the most mature. Maturation is associated with Decrease…
Anemia… Laboratory diagnosis of Iron Deficiency 7 Mar 20134 Feb 2014 The investigation to diagnose iron deficiency include: Haemoglobin and red cell parameters Bone marrow iron staining Serum Iron, total iron binding capacity and transferrin saturation Serum ferritin Zinc Protoporphyrin Soluble…
Bone Marrow Examination… Orthochromatophilic Normoblast 7 Mar 20137 Mar 2013 Orthochromatophilic normoblast An orthochromatophilic normoblast is the most mature of nut;elated red cell precursors. The cytoplasm has lost almost all it's basophilia and is the same colour as that of…
Erythropoiesis… Embryonic Haemoglobins 24 Oct 20127 Jun 2016 Embryonic haemglobins are haemoglobins produced in the yolk sac stage of erythropoiesis. There are three embryonic haemoglobins Gower I, Gower II and Portland. Embryonic haemoglobins like their adult counterparts are…
Bone Marrow Examination… Megaloblasts 25 Jul 20123 Jan 2015 Development of erythrocytes involves coordinated changes in the nucleus and the cytoplasm of erythroid processors (see Morphology of Erythroid Precursors) . The proerythroblast is a large cell with a fine…
Erythropoiesis… Basophilic and Polychromatophilic Normoblasts 22 May 201213 Jun 2012 The adjacent image shows three erythroid cells, two polychromatophilic normoblasts on the sides and a basophilic normoblasts between the two cells. The color of cytoplasm of erythroid cells is balance…
Erythropoiesis… Erythropoietin and Erythropoietin Receptor 23 Dec 201122 Jun 2017 (Post updated on June 21st 2017) Erythropoietin (EPO), a 34kD 166 amino acid polypeptide, is the main regulator of erythrocyte production. It acts via the erythropoietin receptor (EPOR). Importance of…
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