Bone Marrow Examination… Multiple Myeloma – Plasma Cells 17 Sep 20131 Feb 2018 Normal plasma cells are 15-20 μm in diameter, have an eccentric nucleus and a pale blue cytoplasm. there is a perinuclear halo which corresponds to the Golgi apparatus. The cytoplasm…
Bone Marrow Examination… Normoblast Maturation 7 Mar 20138 Mar 2013 The image above shows three polychromatophilic normoblasts. The one on the left is the least mature and the one on the right the most mature. Maturation is associated with Decrease…
Bone Marrow Examination… Orthochromatophilic Normoblast 7 Mar 20137 Mar 2013 Orthochromatophilic normoblast An orthochromatophilic normoblast is the most mature of nut;elated red cell precursors. The cytoplasm has lost almost all it's basophilia and is the same colour as that of…
Bone Marrow Examination… Megaloblasts 25 Jul 20123 Jan 2015 Development of erythrocytes involves coordinated changes in the nucleus and the cytoplasm of erythroid processors (see Morphology of Erythroid Precursors) . The proerythroblast is a large cell with a fine…
Bone Marrow Examination… Osteoclast Morphology 18 Jun 201219 Jun 2012 This was a 32 year old patient whose bone marrow aspiration was done for a suspected diagnosis of a leukaemia. The aspirate yielded a scanty amount of pauciparticulate marrow. Blasts…
Acute Promyelocytic Leukemia… Faggot Cells 30 May 201213 Jun 2012 The old/middle english term faggot means a bundle of sticks bound together as fuel (faggot is derived the latin term fascis which is also the root for the term fasiculus).…
Bone Marrow Examination… Megakaryocyte Morphology 22 Dec 201123 Aug 2013 Megakaryocytes, the precursors of platelets, are the largest cells in the bone marrow. They are the earliest morphologically recognizable cells of the megakaryocyte-platelet lineage. Megakaryocytes arise from the stem cell…
Acute Myeloid Leukemia… Auer Rods 10 Jun 20118 Jul 2012 Auer rods are needle shaped azurophilic intracytoplasmic inclusion bodies described by John Auer in 1906. They are 0.1-2μ wide and 3-6μ long and are formed by fusion of lysosomes. They…
Bone Marrow Examination… Morphology of Myeloid Precurssors 4 Jun 201126 May 2016 The earliest morphologically distinct myeloid cell is a myeloblast. Cell with myeloid commitment at stages of differentiation between the pleuripotant stem cell and myeloblasts have been identified but these lack…
Anemia… Neutrophil Segmentation and Projections 18 May 20118 Jul 2012 The neutrophil nucleus is segmented. The nucleus of the most immature neutrophil, band neutrophil lacks segmentation. It differs from a metamyelocyte in that the concave and convex surfaces of the…
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