Diagnosis… Lymphocytosis in Adults 28 Sep 201728 Sep 2017 Normal Peripheral Blood Lymphocytes Lymphocytes are small leucocytes with a round nucleus and a thin rim of cytoplasm. About 10% of the peripheral lymphocytes are large, have a more abundant…
Anemia… Anaemia with Hyperbilirubinaemia 8 Jun 201610 Jun 2016 A 49-year-old female presented with dyspnoea on exertion of 1 month duration. Examination reviled pallor and icterus. There was no lymphadenopathy, clubbing, koilonychia, platonychia, petechiae or purpura. There was no oedema…
Calreticulin Mutations… Calreticulin and Myeloproliferative Neoplasm 12 May 20165 Sep 2017 Myeloproliferative neoplasm (polycythaemia vera [PV], essential thrombocytosis [ET], progressive myelofibrosis [PMF]) are a group of diseases that are characterised by increased proliferation of blood cells, splenomegaly, myelofibrosis, thrombosis and risk…
Acute Lymphoblastic Leukaemia… The BCR-ABL1 Gene 27 Sep 20153 Dec 2015 BCR-ABL1 is a fusion gene formed as a result of the t(9;22)(q34;q11) chromosomal translocation, the translocation that results in the formation of the Philadelphia chromosome. The Abelson murine leukaemia viral…
aPTT… Factor XII 24 Dec 2014 Factor XII is a coagulation factor that initiates the intrinsic (contact) coagulation system. It is for this reason that it is also known as contact factor. It was described in…
aPTT… Evaluation of a Bleeding Patinet 27 Nov 201427 Nov 2014 From the point of evaluation of a bleeding patients haemostasis can be divided into the following parts. Platelets, Vessel wall Coagulation system: The coagulation system has the three parts intrinsic…
Coagulation Tests… Thrombin Time 16 Oct 201416 Oct 2014 Thrombin time is the clotting time of plasma on addition of thrombin. It measures the amount and quality of fibrinogen. Thrombin time is prolonged when the fibrinogen levels fall below…
Diagnosis… Erythrocyte Sedimentation Rate 14 Oct 201414 Oct 2014 Erythrocyte Sedimentation rate (ESR) is test for acute phase reactants. It was it was described by Edmund Bienracki (S Afr Med J. 2006; 96:40-1). Though it is a commonly performed…
aPTT… Activated Partial Thromboplastin Test 2 Oct 20142 Oct 2014 Activated partial thrombocplastin time (aPTT) measures the efficiency of the contact activation of clotting. It depends on factor XII, XI, IX, VIII, V and X. Principle Plasma is incubated with…
Acute Lymphoblastic Leukaemia… Leukaemia – The Peripheral Smear 10 Jul 2014 Differentiating Acute and Chronic Leukaemia Leucocytosis with anaemia is a feature of acute and chronic leukaemia. It is possible to differentiate acute and chronic leukaemia by looking at the peripheral…
All About Blood 