Evolution and Spread of HbS

20 Jun 201620 Jun 2016

The gene for β globin (OMIM  is present on chromosome 11 (11p15.4) along with other globin genes (ε, γ, γ and δ). This is known as the β-globin cluster .…

The BCR-ABL1 Gene

27 Sep 20153 Dec 2015

BCR-ABL1 is a fusion gene formed as a result of the t(9;22)(q34;q11) chromosomal translocation, the translocation that results in the formation of the Philadelphia chromosome. The Abelson murine leukaemia viral…

Dominant-Negative Phenotype

3 Jan 2015

The human genome has two alleles of any gene. An allele may be dominant, recessive or co-domainant. Only one copy of an allele is needed for a dominant allele to…