Acute Lymphoblastic Leukaemia… Evaluation of Splenomegaly 17 May 201717 May 2017 The spleen is a secondary lymphoid organ that lies in intraperitoneally in the left hypochondrium, abuting the diaphragm. It spans from the 9th to 11th rib and weighs between 150-200g. Spleen…
BCR-ABL inhibitors… Chronic Myeloid Leukaemia 15 Apr 201615 Jun 2016 Chronic myeloid leukaemia (CML) is a myeloproliferative disorder characterised by anaemia, leucocytosis and splenomegaly. The natural history of CML is characterised by three phases chronic phase, accelerated phase (AP) and blast phase…
Acute Lymphoblastic Leukaemia… The BCR-ABL1 Gene 27 Sep 20153 Dec 2015 BCR-ABL1 is a fusion gene formed as a result of the t(9;22)(q34;q11) chromosomal translocation, the translocation that results in the formation of the Philadelphia chromosome. The Abelson murine leukaemia viral…
Acute Lymphoblastic Leukaemia… Tumour Lysis Syndrome 9 Oct 20149 Oct 2014 Rapid tumour lysis can release harmful metabolites at a rate that exceeds the kidney's excretory capacity resulting in a metabolic syndrome known as tumour lysis syndrome (TLS). TLS is a complex…
Bendamustine… Bendamustine 1 Aug 2014 Bendamustine is a mechlorethamine derivative synthesised by Ozegowski and Krebs from the former East Germany in 1963. The molecule has three parts, The alkylator mechloethamine, Benzimidazole ring that mimics purines…
Chronic Myeloid Leukaemia… Hydroxyurea – Drug Information 15 Jul 201415 Jul 2014 Hydroxyurea was synthesised in Germany in 1860 and was found inhibit granulocyte production. It was only a hundred years after this that its potential as an anticancer drug was realized.…
Acute Lymphoblastic Leukaemia… Hyperleukocytosis and Leukostasis 10 Jul 20146 Sep 2017 Leukostasis is a oncological emergency seen in patients with leukaemia who present with pronounced leucocytosis. It is seen in about 5-30% of adult acute leukaemia cases. It results from slugging of microcirculation…
Acute Lymphoblastic Leukaemia… Leukaemia – The Peripheral Smear 10 Jul 2014 Differentiating Acute and Chronic Leukaemia Leucocytosis with anaemia is a feature of acute and chronic leukaemia. It is possible to differentiate acute and chronic leukaemia by looking at the peripheral…
Acute Lymphoblastic Leukaemia… Osteonecrosis in Acute Lymphoblastic Leukaemia (ALL) 10 Nov 2013 Corticosteroids are an important component of treatment of childhood ALL. The use of corticosteroids ahs been associated with osteonecrosis. The estimates of osteonecrosis have varied from 7.4%-44%. About 25% of…
Acute Lymphoblastic Leukaemia… Dasatinib 26 Jul 2013 Dasatinib is a thiazole carboxamide oral multikinase inhibitor that inhibits BCR-ABL and SRC kinases that is used for the treatment of chronic myeloid leukaemia and BCR-ABL positive acute lymphoblastic leukaemia.…
All About Blood 