Acute Lymphoblastic Leukaemia… The BCR-ABL1 Gene 27 Sep 20153 Dec 2015 BCR-ABL1 is a fusion gene formed as a result of the t(9;22)(q34;q11) chromosomal translocation, the translocation that results in the formation of the Philadelphia chromosome. The Abelson murine leukaemia viral…
Acute Lymphoblastic Leukaemia… Tumour Lysis Syndrome 9 Oct 20149 Oct 2014 Rapid tumour lysis can release harmful metabolites at a rate that exceeds the kidney's excretory capacity resulting in a metabolic syndrome known as tumour lysis syndrome (TLS). TLS is a complex…
Acute Lymphoblastic Leukaemia… Hyperleukocytosis and Leukostasis 10 Jul 20146 Sep 2017 Leukostasis is a oncological emergency seen in patients with leukaemia who present with pronounced leucocytosis. It is seen in about 5-30% of adult acute leukaemia cases. It results from slugging of microcirculation…
Acute Lymphoblastic Leukaemia… Leukaemia – The Peripheral Smear 10 Jul 2014 Differentiating Acute and Chronic Leukaemia Leucocytosis with anaemia is a feature of acute and chronic leukaemia. It is possible to differentiate acute and chronic leukaemia by looking at the peripheral…
Acute Myeloid Leukemia… Cluster of Differentiation 20 Mar 201220 Mar 2012 Table 1 Cluster of differentiation was proposed as a system to classify monoclonal antibodies. The antibodies, their cluster of differentiation and their linage is listed in the table above The…
Acute Myeloid Leukemia… Auer Rods 10 Jun 20118 Jul 2012 Auer rods are needle shaped azurophilic intracytoplasmic inclusion bodies described by John Auer in 1906. They are 0.1-2μ wide and 3-6μ long and are formed by fusion of lysosomes. They…
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