BCR-ABL inhibitors… Chronic Myeloid Leukaemia 15 Apr 201615 Jun 2016 Chronic myeloid leukaemia (CML) is a myeloproliferative disorder characterised by anaemia, leucocytosis and splenomegaly. The natural history of CML is characterised by three phases chronic phase, accelerated phase (AP) and blast phase…
Acute Lymphoblastic Leukaemia… The BCR-ABL1 Gene 27 Sep 20153 Dec 2015 BCR-ABL1 is a fusion gene formed as a result of the t(9;22)(q34;q11) chromosomal translocation, the translocation that results in the formation of the Philadelphia chromosome. The Abelson murine leukaemia viral…
Chronic Myeloid Leukaemia… Hydroxyurea – Drug Information 15 Jul 201415 Jul 2014 Hydroxyurea was synthesised in Germany in 1860 and was found inhibit granulocyte production. It was only a hundred years after this that its potential as an anticancer drug was realized.…
Acute Lymphoblastic Leukaemia… Hyperleukocytosis and Leukostasis 10 Jul 20146 Sep 2017 Leukostasis is a oncological emergency seen in patients with leukaemia who present with pronounced leucocytosis. It is seen in about 5-30% of adult acute leukaemia cases. It results from slugging of microcirculation…
Acute Lymphoblastic Leukaemia… Leukaemia – The Peripheral Smear 10 Jul 2014 Differentiating Acute and Chronic Leukaemia Leucocytosis with anaemia is a feature of acute and chronic leukaemia. It is possible to differentiate acute and chronic leukaemia by looking at the peripheral…
Acute Lymphoblastic Leukaemia… Dasatinib 26 Jul 2013 Dasatinib is a thiazole carboxamide oral multikinase inhibitor that inhibits BCR-ABL and SRC kinases that is used for the treatment of chronic myeloid leukaemia and BCR-ABL positive acute lymphoblastic leukaemia.…
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