Skip to content

All About Blood

…. Of blood and diseases of blood

Search
  • Home
    • Pathogenesis of Disease
  • Diseases
    • Lymphoma
      • Nodular Lymphocytic Predominant Hodgkin’s Lymphoma
    • Haematological Emergencies
      • Superior Vana Caval Syndrome
      • Overwhelming Post-Splenectomy Infection
  • Manifestation of Disease
    • Evaluating Anaemia
    • Types of Bleeding
    • Clinical Features of Megaloblastic Anaemia
    • Clinical Features of Antiphospholipid Syndromes
  • Laboratory Tests
    • ESR
    • Haemogram
      • Lymphocytosis in Adults
      • Platelet Counts and Platelet Indices
    • Laboratory Evaluation of Coagulation
      • Activated Partial Thromboplastin Time
      • Bleeding Time
      • Mixing Studies
      • Prothrombin Time
    • Reticulocyte Count
  • Cases And Atlas
    • Haematology Atlas
      • Haematopathology
      • Radiology
      • Clinical Manifestations
    • Cases
      • Anaemia
        • Severe Microcytic Anaemia
        • Anaemia with Thrombocytosis
        • Anaemia with Hyperbilirubinaemia
      • Platelet and Coagulation
        • Thrombocytopenia Due to Large Platelets

Category: Pathogenesis of Disease

Anti-coagulants…

Vitamin K

6 Jun 20186 Jun 2018
Vitamin K was discovered by Henrik Dam in 1929 while studying cholesterol metabolism in chicken (see Discovery of Vitamin K and It's Targets and Antagonists). It is a co-factor for post translation…
Acute Lymphoblastic Leukaemia…

The BCR-ABL1 Gene

27 Sep 20153 Dec 2015
BCR-ABL1 is a fusion gene formed as a result of the t(9;22)(q34;q11) chromosomal translocation, the translocation that results in the formation of the Philadelphia chromosome. The Abelson murine leukaemia viral…
Genetics…

Dominant-Negative Phenotype

3 Jan 2015
The human genome has two alleles of any gene. An allele may be dominant, recessive or co-domainant. Only one copy of an allele is needed for a dominant allele to…
aPTT…

Factor XII

24 Dec 2014
Factor XII is a coagulation factor that initiates the intrinsic (contact) coagulation system. It is for this reason that it is also known as contact factor. It was described in…
Bleeding Disorders…

Factor XI

14 Dec 2014
Factor XI, also known as plasma thromboplastin antecedent, is a zymogen of factor XIa. It is involved in activation of the intrinsic coagulation pathway. Unlike factor XII, prekallikrein and high-molecular…
Haemachromatosis…

Transferrin and Transferrin Receptors

27 Sep 2014
Free iron is toxic by its ability to generate oxygen free radicals and cause damage to macromolecules. Iron in transported in the plasma bound to transferrin. Uptake of transferrin by the…
Acute Lymphoblastic Leukaemia…

Hyperleukocytosis and Leukostasis

10 Jul 20146 Sep 2017
Leukostasis is a oncological emergency seen in patients with leukaemia who present with pronounced leucocytosis. It is seen in about 5-30% of adult acute leukaemia cases. It results from slugging of microcirculation…
Pathogenesis of Disease…

Proteasome

1 Jun 201420 Feb 2017
Proteasome Cell catabolise proteins by two pathways, lysosome and proteasome. Proteasome is an ATP dependent pathway that plays a critical role in growth and development of the cell by degrading…
Anemia…

The Erythrocyte Membrane

4 Feb 201411 Oct 2017
Compared to other cells of the body the erythrocyte, consistent with its simple functional requirements, has a simple structure. The erythrocyte delivers oxygen to tissue and aids in carriage of…
Anemia…

Intestinal Iron Absorption

18 Jan 201429 Apr 2017
Intestinal absorption of iron (figure 1) Iron absorption occurs in two steps Absorption of iron into the enterocyte at the luminal surface of the enterocytes Transport of iron to the…

Posts navigation

Older posts

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 11,441 other subscribers

Blog Stats

  • 789,421 hits

Recent Posts

  • Manifestations of Disease – MCQ – 1
  • MCQ – Haemoglobinopathy
  • Photo Quiz – 1
  • MCQ – Microcytic Anaemia
  • Regulation of Haematopoiesis

Top Posts & Pages

  • Haemoglobin Catabolism
  • Home
  • Diseases
  • Manifestation of Disease
  • Laboratory Tests
  • Cases And Atlas
Create a free website or blog at WordPress.com.
Privacy & Cookies: This site uses cookies. By continuing to use this website, you agree to their use.
To find out more, including how to control cookies, see here: Cookie Policy
  • Follow Following
    • All About Blood
    • Join 313 other followers
    • Already have a WordPress.com account? Log in now.
    • All About Blood
    • Customize
    • Follow Following
    • Sign up
    • Log in
    • Report this content
    • View site in Reader
    • Manage subscriptions
    • Collapse this bar
 

Loading Comments...