Photo Quiz – 1

30 Apr 201930 Apr 2019

The leucocyte on the left is a monocyte. The two leukocytes on the right are neutrophils. MonocytesMonocytes are components of the reticuliendothelial system. They mature into tissue macrophages. Shape: They…

78 year old Alcoholic With Anaemia

29 Oct 201729 Oct 2017

An 78 year old man presented with fatigue and breathlessness. Examination showed pallor. There was no icretus, clubbing, lymphadenopathy or hepatomegaly. There was mild splenomegaly. There was no history of haemoptysis,…

Superior Vana Caval Syndrome

23 Sep 2016

Superior Vena Caval Syndrome (SVCS) results from a space occupying lesion (SOL) in the superior mediastinum. The presence of a SOL results in compression of structures passing through the mediastinum. The…

The M-Band

29 Jun 201610 Jun 2018

What is an M-Band? Immunoglobulins are antigen binding molecules secreted by plasma cells. Immunoglobulins bind antigens and play a role acquired immunity. Plasma cells develop from antigen exposed B-lymphocytes. The…

Anaemia with Hyperbilirubinaemia

8 Jun 201610 Jun 2016

A 49-year-old female presented with dyspnoea on exertion of 1 month duration. Examination reviled pallor and icterus. There was no lymphadenopathy, clubbing, koilonychia, platonychia, petechiae or purpura. There was no oedema…

Calreticulin and Myeloproliferative Neoplasm

12 May 20165 Sep 2017

Myeloproliferative neoplasm (polycythaemia vera [PV], essential thrombocytosis [ET], progressive myelofibrosis [PMF]) are a group of diseases that are characterised by increased proliferation of blood cells, splenomegaly, myelofibrosis, thrombosis and risk…

Chronic Myeloid Leukaemia

15 Apr 201615 Jun 2016

Chronic myeloid leukaemia (CML) is a myeloproliferative disorder characterised by anaemia, leucocytosis and splenomegaly. The natural history of CML is characterised by three phases chronic phase, accelerated phase (AP) and blast phase…

Dominant-Negative Phenotype

3 Jan 2015

The human genome has two alleles of any gene. An allele may be dominant, recessive or co-domainant. Only one copy of an allele is needed for a dominant allele to…

Dictionary

30 Sep 201430 Sep 2015

Fusion Gene Fusion gene is a abarant gene is a gene formed by fusion of parts of two genes. Fusion genes result are important drivers of malignancy. Many have been…

Prothrombin Time

19 Aug 201322 Aug 2013

Prothrombin time was described by Quick in 1935. It is the time taken by re-calcified plasma to clot in the presence of tissue procoagulant extract known as thromboplastin. It asses…