Disease Monograph… Febrile Non-Haemolytic Transfusion Reaction 8 Jun 2018 Febrile non-haemolytic transfusion reaction (FNHTR) is the most common transfusion reaction. Its needs to be differentiated from haemolytic transfusion reaction and bacterial contamination both of which are serious and potentially…
Complications of Treatment… Transfusion Associated Acute Lung Injury (TRALI) 26 Sep 201426 Sep 2014 TRALI is a severe transfusion reaction associated with antibodies to leukocyte antigens present in transfused plasma. It was first described by Brittigham in 1957 (Vox Sang 1957;2:242-248). It is estimated…
Bleeding Disorders… Cryoprecipitate and Cryosupernatant 10 Aug 2013 Cryoprecipitate is prepared by a controlled thawing of frozen plasma. The plasma warmed to between 1-6° C. The high molecular proteins remain as precipitate. This precipitate is centrifuged and suspended…
Anemia… Case No 1 – Severe Microcytic Anaemia 1 Nov 20125 Nov 2012 A 17-year-old woman from a farming community presented with the history of severe weakness, fatigue and dyspnoea on moderate exertion. She was well till about 4 months before presentation when…
Anemia… Red Cell Distribution Width 1 Oct 2012 Features of peripheral smear like erythrocyte size, haemoglobinization and variability in size have long been useful in evaluation of patients with anaemia. The definitions of these parameters before the advent of…
Transfusion Medicine Transfusion Associated Graft vs. Host Disease 12 Jul 2012 Mismatched organ transplantation results in rejection that is mediated by T lymphocytes. What would happen if the T-lymphocytes cells were transplanted into an HLA-incompatible host? If the transplanted T-lymphocytes survive…
Transfusion Medicine Complications of Blood and Blood Product Transfusion 29 May 201226 Sep 2014 IMMUNE COMPLICATION Haemolytic transfusion reactions: Haemolysis following red cell transfusion occur in two forms. Acute haemolysis occurs within 24 hours, is more serious and usually intravascular. Delayed haemolysis occurs after…
Laboratory Tests… The ABO (ABH) Blood Group System 17 Apr 201228 Sep 2017 The risk of transfusion reactions prevented widespread use of blood transfusion till the turn of the 20th centaury. In 1900 Karl Landsteiner while mixing red cells and serum from his…
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