Chronic Neutrophilic Leukaemia… Overview of Myeloproliferative Neoplasm 5 Sep 20171 Feb 2018 Myeloproliferative neoplasm are a group of disorders characterized by bone marrow proliferation with increase in the number of blood cells. The proliferation my be limited to one cell line or…
Acute Lymphoblastic Leukaemia… Evaluation of Splenomegaly 17 May 201717 May 2017 The spleen is a secondary lymphoid organ that lies in intraperitoneally in the left hypochondrium, abuting the diaphragm. It spans from the 9th to 11th rib and weighs between 150-200g. Spleen…
Acute Lymphoblastic Leukaemia… The BCR-ABL1 Gene 27 Sep 20153 Dec 2015 BCR-ABL1 is a fusion gene formed as a result of the t(9;22)(q34;q11) chromosomal translocation, the translocation that results in the formation of the Philadelphia chromosome. The Abelson murine leukaemia viral…
Chronic Myeloid Leukaemia… Hydroxyurea – Drug Information 15 Jul 201415 Jul 2014 Hydroxyurea was synthesised in Germany in 1860 and was found inhibit granulocyte production. It was only a hundred years after this that its potential as an anticancer drug was realized.…
Acute Lymphoblastic Leukaemia… Hyperleukocytosis and Leukostasis 10 Jul 20146 Sep 2017 Leukostasis is a oncological emergency seen in patients with leukaemia who present with pronounced leucocytosis. It is seen in about 5-30% of adult acute leukaemia cases. It results from slugging of microcirculation…
Acute Lymphoblastic Leukaemia… Leukaemia – The Peripheral Smear 10 Jul 2014 Differentiating Acute and Chronic Leukaemia Leucocytosis with anaemia is a feature of acute and chronic leukaemia. It is possible to differentiate acute and chronic leukaemia by looking at the peripheral…
Acute Lymphoblastic Leukaemia… Dasatinib 26 Jul 2013 Dasatinib is a thiazole carboxamide oral multikinase inhibitor that inhibits BCR-ABL and SRC kinases that is used for the treatment of chronic myeloid leukaemia and BCR-ABL positive acute lymphoblastic leukaemia.…
Uncategorized Determinants of Blood Viscosity 19 Mar 201219 Mar 2012 Fluids flow on application of pressure. The flow may be laminar flow that is orderly in parallel layers or turbulent flow that is chaotic. During laminar flow the layer closest…
Anemia… Neutrophil Segmentation and Projections 18 May 20118 Jul 2012 The neutrophil nucleus is segmented. The nucleus of the most immature neutrophil, band neutrophil lacks segmentation. It differs from a metamyelocyte in that the concave and convex surfaces of the…
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