Overview of Myeloproliferative Neoplasm

5 Sep 20171 Feb 2018

Myeloproliferative neoplasm are a group of disorders characterized by bone marrow proliferation with increase in the number of blood cells. The proliferation my be limited to one cell line or…

Anaemia of Renal Insufficiency

24 Aug 201724 Aug 2017

Richard Bright discovered the relationship of renal failure and anaemia in 1836. Anaemia of renal insufficiency is mainly results from decreased erythropoietin production and impaired supply of iron to erythroid…

Anaemia with Thrombocytosis

8 Aug 20178 Aug 2017

A 49 year old woman presented with weakness and fatigability. On examination, other than pallor of the skin and mucosa there was no other finding.  A haemogram was done that…

Heme Synthesis

3 Aug 20177 Aug 2017

Heme, a porphyrin, is a co-factor in haemoglobin, myoglobin, cytochrome, catalase, heme peroxidase, and endothelial nitric oxide synthase. It has a complex structure with four pyrrole rings with a ferrous…

Drugs and Eosinophilia

25 Jan 20173 Feb 2017

Drugs, prescription and non-prescription,  and nutritional supplements are a common cause of eosinophilia across the world. In regions with a low prevalence of parasitic infestations drugs are the leading cause…

Clinical Features of Megaloblastic Anaemia

2 Jul 20162 Jul 2016

Megaloblastic anaemia is a macrocytic anaemia resulting from the deficiency of vitamin B12 or folic acid characterised by the presence of megaloblasts in the bone marrow. It has haematological and neurological…

The M-Band

29 Jun 201610 Jun 2018

What is an M-Band? Immunoglobulins are antigen binding molecules secreted by plasma cells. Immunoglobulins bind antigens and play a role acquired immunity. Plasma cells develop from antigen exposed B-lymphocytes. The…

Evolution and Spread of HbS

20 Jun 201620 Jun 2016

The gene for β globin (OMIM  is present on chromosome 11 (11p15.4) along with other globin genes (ε, γ, γ and δ). This is known as the β-globin cluster .…

Anaemia with Hyperbilirubinaemia

8 Jun 201610 Jun 2016

A 49-year-old female presented with dyspnoea on exertion of 1 month duration. Examination reviled pallor and icterus. There was no lymphadenopathy, clubbing, koilonychia, platonychia, petechiae or purpura. There was no oedema…

Calreticulin and Myeloproliferative Neoplasm

12 May 20165 Sep 2017

Myeloproliferative neoplasm (polycythaemia vera [PV], essential thrombocytosis [ET], progressive myelofibrosis [PMF]) are a group of diseases that are characterised by increased proliferation of blood cells, splenomegaly, myelofibrosis, thrombosis and risk…