Burkitt's Lymphoma… Classification of Lymphoma 3 May 20161 Feb 2018 Lymphomas are a group of malignancies arising from lymphoid tissue. They have a diverse etiology, pathogenesis, clinical presentation, treatment and outcomes. Morphology alone is insufficient to classify lymphomas but for a long…
Classical Hodgkin Lymphoma… From Hodgkin’s Disease to Hodgkin Lymphoma 21 Oct 201521 Oct 2015 Hodgkin lymphoma was described by Thomas Hodgkin in 1932. It was referred to as Hodgkin's disease till the WHO classification proposed the use of the term Hodgkin Lymphoma. The journey…
Anemia… Classification of β-Thalassaemia 14 Oct 2015 β-Thalassaemia is a term applied to describe heterozygous group of diseases that are characterised by a decrease in the production of β globin chain. Over 200 mutations in the β-globin gene and…
Acute Lymphoblastic Leukaemia… The BCR-ABL1 Gene 27 Sep 20153 Dec 2015 BCR-ABL1 is a fusion gene formed as a result of the t(9;22)(q34;q11) chromosomal translocation, the translocation that results in the formation of the Philadelphia chromosome. The Abelson murine leukaemia viral…
Clonal Plasma Cell Disorder… Staging of Multiple Myeloma 23 Sep 201523 Sep 2015 Cancer is a heterogenous disease in terms of survival. Cancer staging is a method to classify patients according to prognosis. More advanced stages are associated with a worse prognosis. Patients…
Genetics… Dominant-Negative Phenotype 3 Jan 2015 The human genome has two alleles of any gene. An allele may be dominant, recessive or co-domainant. Only one copy of an allele is needed for a dominant allele to…
Diffuse Large B Cell Lymphoma… Primary Cutaneous DLBCL – Leg Type 1 Jan 2015 The first description of a primary cutaneous diffuse large B cell lymphoma was by Willemze et al in 1987 who described a group of elderly women with cutaneous large cell…
Clinical Evaluation… Manifestations of Lymphoma 30 Dec 201424 May 2016 Lymphomas are the most prevalent haematological malignancies. They are highly curable particularly in the early stage. As is the case with all cancers, there are no symptoms typical of lymphoma.…
aPTT… Factor XII 24 Dec 2014 Factor XII is a coagulation factor that initiates the intrinsic (contact) coagulation system. It is for this reason that it is also known as contact factor. It was described in…
Bleeding Disorders… Factor XI 14 Dec 2014 Factor XI, also known as plasma thromboplastin antecedent, is a zymogen of factor XIa. It is involved in activation of the intrinsic coagulation pathway. Unlike factor XII, prekallikrein and high-molecular…
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