Anemia… Intravenous Iron 9 Apr 201418 Sep 2016 Iron deficiency, the commonest cause of anaemia, is treated by iron supplementation. Oral iron, introduced by the French physician Pierre Blaud in the 19th century is the mainstay of therapy…
Erythropoiesis… Etiology of Polycythaemia 13 Jul 201313 Jul 2013 The terms polycythemia and erythrocytosis though used interchangeably describe different entities. Polycythemia (Gk, polys + kytos, cell, haima, blood) is an absolute increase in the mass of red cells. Erythrocytosis refers to only increase in the concentration…
Diagnosis… Myelocyte and Neutrophils – Band and Segmented 18 Mar 201318 Mar 2013 The image about shows morphology of cells of the neutrophilic series. The first cell to show commitment to a particular granulcoytic series (eosinophilic, basophilic or eosinophilic) is the promyelocyte. The…
Bone Marrow Examination… Normoblast Maturation 7 Mar 20138 Mar 2013 The image above shows three polychromatophilic normoblasts. The one on the left is the least mature and the one on the right the most mature. Maturation is associated with Decrease…
Bone Marrow Examination… Orthochromatophilic Normoblast 7 Mar 20137 Mar 2013 Orthochromatophilic normoblast An orthochromatophilic normoblast is the most mature of nut;elated red cell precursors. The cytoplasm has lost almost all it's basophilia and is the same colour as that of…
Erythropoiesis… Embryonic Haemoglobins 24 Oct 20127 Jun 2016 Embryonic haemglobins are haemoglobins produced in the yolk sac stage of erythropoiesis. There are three embryonic haemoglobins Gower I, Gower II and Portland. Embryonic haemoglobins like their adult counterparts are…
Bone Marrow Examination… Megaloblasts 25 Jul 20123 Jan 2015 Development of erythrocytes involves coordinated changes in the nucleus and the cytoplasm of erythroid processors (see Morphology of Erythroid Precursors) . The proerythroblast is a large cell with a fine…
Anemia Bone Marrow Involvement by Cancer 16 Jun 2012 A 48 year old women presented with backache. The MRI suggested the presence of a metastatic involvement of multiple vertebrae. The biopsy from D11 showed it to involved by an…
Erythropoiesis… Basophilic and Polychromatophilic Normoblasts 22 May 201213 Jun 2012 The adjacent image shows three erythroid cells, two polychromatophilic normoblasts on the sides and a basophilic normoblasts between the two cells. The color of cytoplasm of erythroid cells is balance…
Erythropoiesis… Erythropoietin and Erythropoietin Receptor 23 Dec 201122 Jun 2017 (Post updated on June 21st 2017) Erythropoietin (EPO), a 34kD 166 amino acid polypeptide, is the main regulator of erythrocyte production. It acts via the erythropoietin receptor (EPOR). Importance of…
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