Disease Monograph… Febrile Non-Haemolytic Transfusion Reaction 8 Jun 2018 Febrile non-haemolytic transfusion reaction (FNHTR) is the most common transfusion reaction. Its needs to be differentiated from haemolytic transfusion reaction and bacterial contamination both of which are serious and potentially…
Haematology Atlas… Monocyte and Neutrophils 6 Dec 2013 The photomicrograph above shows a monocyte (left) and two neutrophils(right) and highlights the differences between the two. The monocyte is mononuclear cell 12-20µm in diameter (about 1.5-2.5 times an erythrocyte).…
Bone Marrow Examination… Multiple Myeloma – Plasma Cells 17 Sep 20131 Feb 2018 Normal plasma cells are 15-20 μm in diameter, have an eccentric nucleus and a pale blue cytoplasm. there is a perinuclear halo which corresponds to the Golgi apparatus. The cytoplasm…
Clonal Plasma Cell Disorder… Biclonal Gammopathy 13 Sep 2013 A 53 year old patient presented with backache. A skeletal survey was performed that showed punched out lesions in the skull. The bone marrow aspiration showed 21% plasma cells. The…
Conventional Imaging… Conventional Radiology in Multiple Myeloma 12 Sep 201313 Sep 2013 There are four monoclonal gammopathies Monoclonal gammopathy of uncertain significance (MGUS) defined as monoclonal component <3g/dL and bone marrow plasma cells less than 10% and no end organ damage.…
Anemia… Sickle Cells 24 Aug 201331 Aug 2013 Sickle Cells 40X Sickle Cells - 100X Sickle Cells - 100X The three photomicrographs above show sickle cells from a patients with sickle cell anemia. Sickle cell anaemia occurs because…
Diagnosis… Chemotherapy Induced Nail Changes 5 Jul 2013 Chemotherapy causes changes in the nails including nail pigmentation, splinter hemorrhage, subungual hematoma, Beau’s lines, acute paronychia and onycholysis. Normal nail growth resumes proximal to distal after all the cycles…
Cytoplasmic Inclusions… Toxic Granules in Neutrophils 23 Mar 2013 Granulocytes have two types of granules primary and secondary. Primary granules are azurophilic, most numerous and prominent at the promyelocyte stage (see morphology of myeloid precursors) and diminish in number…
Haematology Atlas… Photomicrography with a Canon 7D SLR 19 Mar 201319 Mar 2013 "Necessity is the mother of invention (or actually discovery in this case)" This blog is developed from a manuscript of a haematology book. No haematology book can be complete without…
Diagnosis… Myelocyte and Neutrophils – Band and Segmented 18 Mar 201318 Mar 2013 The image about shows morphology of cells of the neutrophilic series. The first cell to show commitment to a particular granulcoytic series (eosinophilic, basophilic or eosinophilic) is the promyelocyte. The…
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