Erythropoiesis… Regulation of Haematopoiesis 23 Mar 2019 All blood cells arise from the haemaopoietic stem cell. The path along which the stem cell progeny matures is dictated by the needs of the body. Examples of this include…
Disease Monograph… Nodular Lymphocytic Predominant Hodgkin’s Lymphoma 20 Oct 201720 Oct 2017 Hodgkin lymphoma (HL) is of two types. Classical (cHL) and nodular lymphocyte predominant (NLPHL). NLPHL is rarer and runs a more indolent clinical course. Epidemiology NLPHL accounts for about 5%…
Acute Lymphoblastic Leukaemia… The BCR-ABL1 Gene 27 Sep 20153 Dec 2015 BCR-ABL1 is a fusion gene formed as a result of the t(9;22)(q34;q11) chromosomal translocation, the translocation that results in the formation of the Philadelphia chromosome. The Abelson murine leukaemia viral…
Diffuse Large B Cell Lymphoma… Primary Cutaneous DLBCL – Leg Type 1 Jan 2015 The first description of a primary cutaneous diffuse large B cell lymphoma was by Willemze et al in 1987 who described a group of elderly women with cutaneous large cell…
Acute Lymphoblastic Leukaemia… Leukaemia – The Peripheral Smear 10 Jul 2014 Differentiating Acute and Chronic Leukaemia Leucocytosis with anaemia is a feature of acute and chronic leukaemia. It is possible to differentiate acute and chronic leukaemia by looking at the peripheral…
Haematology Atlas… Monocyte and Neutrophils 6 Dec 2013 The photomicrograph above shows a monocyte (left) and two neutrophils(right) and highlights the differences between the two. The monocyte is mononuclear cell 12-20µm in diameter (about 1.5-2.5 times an erythrocyte).…
Bone Marrow Examination… Multiple Myeloma – Plasma Cells 17 Sep 20131 Feb 2018 Normal plasma cells are 15-20 μm in diameter, have an eccentric nucleus and a pale blue cytoplasm. there is a perinuclear halo which corresponds to the Golgi apparatus. The cytoplasm…
Anemia… Sickle Cells 24 Aug 201331 Aug 2013 Sickle Cells 40X Sickle Cells - 100X Sickle Cells - 100X The three photomicrographs above show sickle cells from a patients with sickle cell anemia. Sickle cell anaemia occurs because…
Anemia… Erythrocyte Metabolism 6 Aug 20137 Aug 2013 As erythrocytes lack mitochondria they are not able to use fats or generate energy from Krebs cycle. Though they have enzymes to synthesize glycogen the balance between synthesis and breakdown…
Cytoplasmic Inclusions… Toxic Granules in Neutrophils 23 Mar 2013 Granulocytes have two types of granules primary and secondary. Primary granules are azurophilic, most numerous and prominent at the promyelocyte stage (see morphology of myeloid precursors) and diminish in number…
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