Anemia… Sickle β-Thalassaemia 24 Sep 201624 Sep 2016 Sickle cell anaemia and β-thalassaemia are two common haemoglobinopathies. Co-inheritance of the two is called sickle β-thalassaemia. Sickle β-thalassaemia seen in Africa, throughout the Mediterranean, Arabian Peninsula and sporadically in india.…
Anemia… Evolution and Spread of HbS 20 Jun 201620 Jun 2016 The gene for β globin (OMIM is present on chromosome 11 (11p15.4) along with other globin genes (ε, γ, γ and δ). This is known as the β-globin cluster .…
Anemia… Sickle Haemoglobin and Varients 14 May 201213 Jun 2012 Substitution of the amino acid glutamic acid by valine at position 6 of the beta globin gene (HBB glu6val) results in a mutant haemoglobin that polymerizes at low oxygen pressure. This…