Erythropoiesis… Regulation of Haematopoiesis 23 Mar 2019 All blood cells arise from the haemaopoietic stem cell. The path along which the stem cell progeny matures is dictated by the needs of the body. Examples of this include…
Disease Monograph… Febrile Non-Haemolytic Transfusion Reaction 8 Jun 2018 Febrile non-haemolytic transfusion reaction (FNHTR) is the most common transfusion reaction. Its needs to be differentiated from haemolytic transfusion reaction and bacterial contamination both of which are serious and potentially…
Coagulation Disorders… Factor VII 7 Jun 2018 Factor VII is a vitamin K dependent coagulation factor. It is a serine protease. Activation of factor VII is the first step in the coagulation cascade. Deficiency is rare and…
Anti-coagulants… Vitamin K 6 Jun 20186 Jun 2018 Vitamin K was discovered by Henrik Dam in 1929 while studying cholesterol metabolism in chicken (see Discovery of Vitamin K and It's Targets and Antagonists). It is a co-factor for post translation…
Anemia… Treatment of Warm Antibody Type Autoimmune Haemolytic Anaemia (WAIHA) 20 Feb 201820 Feb 2018 Warm antibody type of autoimmune haemolytic anaemia (WAIHA) is characterised by anaemia, reticulocytosis, conjugated hyperbilirubinaemia with the presence of a positive anti-globulin (Coombs') test (see Diagnosis of haemolytic anaemia). It may…
Disease Monograph… Nodular Lymphocytic Predominant Hodgkin’s Lymphoma 20 Oct 201720 Oct 2017 Hodgkin lymphoma (HL) is of two types. Classical (cHL) and nodular lymphocyte predominant (NLPHL). NLPHL is rarer and runs a more indolent clinical course. Epidemiology NLPHL accounts for about 5%…
Chronic Neutrophilic Leukaemia… Overview of Myeloproliferative Neoplasm 5 Sep 20171 Feb 2018 Myeloproliferative neoplasm are a group of disorders characterized by bone marrow proliferation with increase in the number of blood cells. The proliferation my be limited to one cell line or…
Anaemia of Renal Insufficiency… Anaemia of Renal Insufficiency 24 Aug 201724 Aug 2017 Richard Bright discovered the relationship of renal failure and anaemia in 1836. Anaemia of renal insufficiency is mainly results from decreased erythropoietin production and impaired supply of iron to erythroid…
Anemia… Anaemia with Thrombocytosis 8 Aug 20178 Aug 2017 A 49 year old woman presented with weakness and fatigability. On examination, other than pallor of the skin and mucosa there was no other finding. A haemogram was done that…
Causes of Disease… Heme Synthesis 3 Aug 20177 Aug 2017 Heme, a porphyrin, is a co-factor in haemoglobin, myoglobin, cytochrome, catalase, heme peroxidase, and endothelial nitric oxide synthase. It has a complex structure with four pyrrole rings with a ferrous…
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