Acquired Coagulation Defects… Clinical Features of Antiphospholipid Syndromes 8 Feb 20188 Feb 2018 Antiphospholipid syndrome (APS) is characterised by venous or arterial thrombosis and/or pregnancy morbidity in the presence of persistent laboratory evidence of antiphospholipid antibodies. It may occur as a primary disorder…
Disease Monograph… Nodular Lymphocytic Predominant Hodgkin’s Lymphoma 20 Oct 201720 Oct 2017 Hodgkin lymphoma (HL) is of two types. Classical (cHL) and nodular lymphocyte predominant (NLPHL). NLPHL is rarer and runs a more indolent clinical course. Epidemiology NLPHL accounts for about 5%…
Anemia… Anaemia with Thrombocytosis 8 Aug 20178 Aug 2017 A 49 year old woman presented with weakness and fatigability. On examination, other than pallor of the skin and mucosa there was no other finding. A haemogram was done that…
Causes of Disease… Heme Synthesis 3 Aug 20177 Aug 2017 Heme, a porphyrin, is a co-factor in haemoglobin, myoglobin, cytochrome, catalase, heme peroxidase, and endothelial nitric oxide synthase. It has a complex structure with four pyrrole rings with a ferrous…
Acute Lymphoblastic Leukaemia… Evaluation of Splenomegaly 17 May 201717 May 2017 The spleen is a secondary lymphoid organ that lies in intraperitoneally in the left hypochondrium, abuting the diaphragm. It spans from the 9th to 11th rib and weighs between 150-200g. Spleen…
Anemia… Oral Iron Therapy 1 May 20171 May 2017 Iron deficiency anaemia is treated by iron supplementation that may be administered orally or parenterally. Oral iron absorption is inefficient, is interfered by food and is associated with high incidence…
Complications of Chemotherapy… Granulocyte Colony Stimulating Factor (G-CSF) 21 Apr 201723 Apr 2017 Neutropenia is a dose limiting toxicity of chemotherapy. It results in delay and dose reduction both of which adversely affect outcomes of treatment. Myeloid growth factors are biological agents that…
Disease Monograph… Drugs and Eosinophilia 25 Jan 20173 Feb 2017 Drugs, prescription and non-prescription, and nutritional supplements are a common cause of eosinophilia across the world. In regions with a low prevalence of parasitic infestations drugs are the leading cause…
Anemia… Sickle β-Thalassaemia 24 Sep 201624 Sep 2016 Sickle cell anaemia and β-thalassaemia are two common haemoglobinopathies. Co-inheritance of the two is called sickle β-thalassaemia. Sickle β-thalassaemia seen in Africa, throughout the Mediterranean, Arabian Peninsula and sporadically in india.…
Anemia… Clinical Features of Megaloblastic Anaemia 2 Jul 20162 Jul 2016 Megaloblastic anaemia is a macrocytic anaemia resulting from the deficiency of vitamin B12 or folic acid characterised by the presence of megaloblasts in the bone marrow. It has haematological and neurological…
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