Case Records… Why Blood Loss From Sites other than Gastrointestinal Tract Rarely Causes Iron Deficiency? 30 Mar 201630 Mar 2016 A 55 year old man presented with breathlessness on climbing stairs. He saw his family physician who found the patient to be pale. The patient was advised a complete haemogram.…
Haemachromatosis… Transferrin and Transferrin Receptors 27 Sep 2014 Free iron is toxic by its ability to generate oxygen free radicals and cause damage to macromolecules. Iron in transported in the plasma bound to transferrin. Uptake of transferrin by the…
Anemia… Intravenous Iron 9 Apr 201418 Sep 2016 Iron deficiency, the commonest cause of anaemia, is treated by iron supplementation. Oral iron, introduced by the French physician Pierre Blaud in the 19th century is the mainstay of therapy…
Anemia… Clinical Manifestation of Iron Deficiency 25 Feb 201425 Feb 2014 The manifestations of Iron deficiency evolve insidiously and are multi-systemic. They include Anaemia Iron deficiency causes hypochromic microcytic anaemia. The anaemia has an insidious onset and the patient may become…
Anemia… Intestinal Iron Absorption 18 Jan 201429 Apr 2017 Intestinal absorption of iron (figure 1) Iron absorption occurs in two steps Absorption of iron into the enterocyte at the luminal surface of the enterocytes Transport of iron to the…
Anemia… Hepcidin and Ferroportin 18 Jan 2014 Iron is an essential micronutrient that is toxic because of its ability to form oxygen free radicals that can damage macromolecules. It is this property of iron that makes it…
Anemia… Microcytic Hypochromic Anaemia 13 Mar 2013 Shown above is an image of hypochromic microcytic anaemia. This patient had iron deficiency anaemia. Microcytosis is presence of small erythrocytes and hypochromia presence of erythrocytes that are poorly haemoglobinized.…
Megakaryopoiesis… Iron Studies in Microcytic Anaemia 8 Mar 20138 Mar 2013 Diagnosis Serum Iron Total Iron Binding Capacity Transferrin1 Serum Ferritin2 Iron deficiency anaemis Low High or Normal <16% <12ng/mL Anaemia of Chronic Disease Normal Low or Normal ≥16% High or…
Anemia… Laboratory diagnosis of Iron Deficiency 7 Mar 20134 Feb 2014 The investigation to diagnose iron deficiency include: Haemoglobin and red cell parameters Bone marrow iron staining Serum Iron, total iron binding capacity and transferrin saturation Serum ferritin Zinc Protoporphyrin Soluble…
Anemia… Case No 1 – Severe Microcytic Anaemia 1 Nov 20125 Nov 2012 A 17-year-old woman from a farming community presented with the history of severe weakness, fatigue and dyspnoea on moderate exertion. She was well till about 4 months before presentation when…
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