Chronic Neutrophilic Leukaemia… Overview of Myeloproliferative Neoplasm 5 Sep 20171 Feb 2018 Myeloproliferative neoplasm are a group of disorders characterized by bone marrow proliferation with increase in the number of blood cells. The proliferation my be limited to one cell line or…
Acute Lymphoblastic Leukaemia… Evaluation of Splenomegaly 17 May 201717 May 2017 The spleen is a secondary lymphoid organ that lies in intraperitoneally in the left hypochondrium, abuting the diaphragm. It spans from the 9th to 11th rib and weighs between 150-200g. Spleen…
Calreticulin Mutations… Calreticulin and Myeloproliferative Neoplasm 12 May 20165 Sep 2017 Myeloproliferative neoplasm (polycythaemia vera [PV], essential thrombocytosis [ET], progressive myelofibrosis [PMF]) are a group of diseases that are characterised by increased proliferation of blood cells, splenomegaly, myelofibrosis, thrombosis and risk…
Acute Lymphoblastic Leukaemia… The BCR-ABL1 Gene 27 Sep 20153 Dec 2015 BCR-ABL1 is a fusion gene formed as a result of the t(9;22)(q34;q11) chromosomal translocation, the translocation that results in the formation of the Philadelphia chromosome. The Abelson murine leukaemia viral…
Chronic Myeloid Leukaemia… Hydroxyurea – Drug Information 15 Jul 201415 Jul 2014 Hydroxyurea was synthesised in Germany in 1860 and was found inhibit granulocyte production. It was only a hundred years after this that its potential as an anticancer drug was realized.…
Acute Lymphoblastic Leukaemia… Hyperleukocytosis and Leukostasis 10 Jul 20146 Sep 2017 Leukostasis is a oncological emergency seen in patients with leukaemia who present with pronounced leucocytosis. It is seen in about 5-30% of adult acute leukaemia cases. It results from slugging of microcirculation…
Acute Lymphoblastic Leukaemia… Leukaemia – The Peripheral Smear 10 Jul 2014 Differentiating Acute and Chronic Leukaemia Leucocytosis with anaemia is a feature of acute and chronic leukaemia. It is possible to differentiate acute and chronic leukaemia by looking at the peripheral…
Erythropoiesis… Etiology of Polycythaemia 13 Jul 201313 Jul 2013 The terms polycythemia and erythrocytosis though used interchangeably describe different entities. Polycythemia (Gk, polys + kytos, cell, haima, blood) is an absolute increase in the mass of red cells. Erythrocytosis refers to only increase in the concentration…
Haematology Atlas… Clinical Manifestations of Polycythaemia 19 Jun 2012 Figure 1. Plethora of the face Figure 2. Plathoric mucosa Figure 3. Palmar erythrma This 50 year old male presented with an incidentally diagnosed haemoglobin of 21.2g/dL. He had no…
Anemia… Neutrophil Segmentation and Projections 18 May 20118 Jul 2012 The neutrophil nucleus is segmented. The nucleus of the most immature neutrophil, band neutrophil lacks segmentation. It differs from a metamyelocyte in that the concave and convex surfaces of the…
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