Acquired Coagulation Defects… Clinical Features of Antiphospholipid Syndromes 8 Feb 20188 Feb 2018 Antiphospholipid syndrome (APS) is characterised by venous or arterial thrombosis and/or pregnancy morbidity in the presence of persistent laboratory evidence of antiphospholipid antibodies. It may occur as a primary disorder…
Diagnosis… Lymphocytosis in Adults 28 Sep 201728 Sep 2017 Normal Peripheral Blood Lymphocytes Lymphocytes are small leucocytes with a round nucleus and a thin rim of cytoplasm. About 10% of the peripheral lymphocytes are large, have a more abundant…
Acute Lymphoblastic Leukaemia… Evaluation of Splenomegaly 17 May 201717 May 2017 The spleen is a secondary lymphoid organ that lies in intraperitoneally in the left hypochondrium, abuting the diaphragm. It spans from the 9th to 11th rib and weighs between 150-200g. Spleen…
Anemia… Sickle β-Thalassaemia 24 Sep 201624 Sep 2016 Sickle cell anaemia and β-thalassaemia are two common haemoglobinopathies. Co-inheritance of the two is called sickle β-thalassaemia. Sickle β-thalassaemia seen in Africa, throughout the Mediterranean, Arabian Peninsula and sporadically in india.…
Anemia… Anaemia with Hyperbilirubinaemia 8 Jun 201610 Jun 2016 A 49-year-old female presented with dyspnoea on exertion of 1 month duration. Examination reviled pallor and icterus. There was no lymphadenopathy, clubbing, koilonychia, platonychia, petechiae or purpura. There was no oedema…
Calreticulin Mutations… Calreticulin and Myeloproliferative Neoplasm 12 May 20165 Sep 2017 Myeloproliferative neoplasm (polycythaemia vera [PV], essential thrombocytosis [ET], progressive myelofibrosis [PMF]) are a group of diseases that are characterised by increased proliferation of blood cells, splenomegaly, myelofibrosis, thrombosis and risk…
Burkitt's Lymphoma… Classification of Lymphoma 3 May 20161 Feb 2018 Lymphomas are a group of malignancies arising from lymphoid tissue. They have a diverse etiology, pathogenesis, clinical presentation, treatment and outcomes. Morphology alone is insufficient to classify lymphomas but for a long…
Classical Hodgkin Lymphoma… From Hodgkin’s Disease to Hodgkin Lymphoma 21 Oct 201521 Oct 2015 Hodgkin lymphoma was described by Thomas Hodgkin in 1932. It was referred to as Hodgkin's disease till the WHO classification proposed the use of the term Hodgkin Lymphoma. The journey…
Anemia… Classification of β-Thalassaemia 14 Oct 2015 β-Thalassaemia is a term applied to describe heterozygous group of diseases that are characterised by a decrease in the production of β globin chain. Over 200 mutations in the β-globin gene and…
Acute Lymphoblastic Leukaemia… The BCR-ABL1 Gene 27 Sep 20153 Dec 2015 BCR-ABL1 is a fusion gene formed as a result of the t(9;22)(q34;q11) chromosomal translocation, the translocation that results in the formation of the Philadelphia chromosome. The Abelson murine leukaemia viral…
All About Blood 