Manifestations of Disease – MCQ – 1

Q1. Which of the following is associated with clubbing and anaemia

1. Bacterial endocarditis
2. Congenital heart disease
3. Thalassaemia Minor
4. Haemoglobin E disease

Q2. Which of the following is not a cause leukopenia

1. Aplastic anaemia
2. Chronic myelocytic leukaemia
3. Acute leukaemia
4. Megaloblastic anaemia

Q3. All the following can cause thrombocytosis except

1. Iron deficiency
2. Chronic inflammation
3. Polycythaemia Vera
4. None of the above

Q4. Which of the following cause leg ulcers

1. Sickle cell anaemia
2. Hereditary spherocytosis
3. Hydroxyurea therapy
4. All of the above

Q5. Which of the following are associated with anaemia and ictrus

1. Paroxysmal nocturnal haemoglobinuria
2. Megaloblastic anaemia
3. Anaemia of lead poisoning
4. Myelodysplastic syndrome

 

 

 

 

 

 

Answers

 

Ans 1. A. Clubbing may be feature of bacterial endocarditis and congenital heart disease. The former is associated with anaemia and the latter with polycythaemia and cyanosis

Ans 2. B. Leukaemia is usually associated with leucocytosis. Acute leukaemia, particularly acute myeloid leukaemia, may present with leukopenia.

Ans 3. D. Iron deficiency, chronic inflammation and polycythaemia vera may all be associated with thrombocytosis.

Ans 4. D. All cause leg ulcers

Ans 5. B. Megaloblastic anaemia is associated with unconjugated hyperbilirubinaemia from death of heamoglobinized erythroid precussors cells.